This study used mass cytometry to create a scientific ‘map’ of the immune system. Then, scientists compared the immune system maps of people with Down syndrome to those without and found that, on average, people with Down syndrome have dysregulation in every detected branch of their immune system…..

In this study, our scientists measured 91 metabolites using mass spectrometry and compared the levels of each metabolite in people with Down syndrome to those without. They found 29 metabolites whose levels were significantly altered in people with Down syndrome. The metabolite that was most significantly elevated was quinolinic acid…..